abstract：:In previous work, we engineered functional cell sheets using bone marrow-derived mesenchymal stem cells (BM-MSCs) to promote islet graft survival. In the present study, we hypothesized that a cell sheet using dermal fibroblasts could be an alternative to MSCs, and then we aimed to evaluate the effects of this cell she...

journal_title：Cell transplantation

authors： Matsushima H,Kuroki T,Adachi T,Kitasato A,Ono S,Tanaka T,Hirabaru M,Kuroshima N,Hirayama T,Sakai Y,Soyama A,Hidaka M,Takatsuki M,Kin T,Shapiro J,Eguchi S

更新日期：2016-01-01 00:00:00

abstract：:Neuronal progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) are an excellent cell source for transplantation therapy due to their availability and ethical acceptability. However, the traditional method of expansion and differentiation of hESCs into NPCs in monolayer cultures requires a long time, ...

journal_title：Cell transplantation

authors： Qiu L,Lim YM,Chen AK,Reuveny S,Oh SK,Tan EK,Zeng L

更新日期：2016-01-01 00:00:00

abstract：:The development of cell- and gene-based strategies for regenerative medicine offers a therapeutic option for the repair and potential regeneration of damaged cardiac tissue post-myocardial infarction (MI). Human umbilical cord subepithelial cell-derived stem cells (hUC-SECs), human bone marrow-derived mesenchymal stem...

journal_title：Cell transplantation

authors： Winters AA,Bou-Ghannam S,Thorp H,Hawayek JA,Atkinson DL,Bartlett CE,Silva FJ,Hsu EW,Moreno AP,Grainger DA,Patel AN

更新日期：2016-01-01 00:00:00

abstract：:Gammopathies, multiple myeloma, and amyloidosis are plasma dyscrasias characterized by clonal proliferation and immunoglobulin overproduction. Renal impairment is the most common and serious complication with an incidence of 20-30% patients at the diagnosis. Kidney transplant has not been considered feasible in the pr...

journal_title：Cell transplantation

authors： Baraldi O,Grandinetti V,Donati G,Comai G,Battaglino G,Cuna V,Capelli I,Sala E,La Manna G

更新日期：2016-01-01 00:00:00

abstract：:Critical length nerve defects in the rat sciatic nerve model were reconstructed with chitosan nerve guides filled with Schwann cells (SCs) containing hydrogel. The transplanted SCs were naive or had been genetically modified to overexpress neurotrophic factors, thus providing a cellular neurotrophic factor delivery sy...

journal_title：Cell transplantation

authors： Meyer C,Wrobel S,Raimondo S,Rochkind S,Heimann C,Shahar A,Ziv-Polat O,Geuna S,Grothe C,Haastert-Talini K

更新日期：2016-01-01 00:00:00

abstract：:Neural progenitor cells (NPCs) overexpressing fibroblast growth factor 2 (FGF-2) have the distinct tendency to associate with the vasculature and establish multiple proliferative clusters in the perivascular environment after transplantation into the cerebral cortex. Strikingly, the vascular clusters of progenitor cel...

journal_title：Cell transplantation

authors： Tsupykov O,Kanemitsu M,Smozhanik E,Skibo G,Dayer AG,Kiss JZ

更新日期：2016-01-01 00:00:00

abstract：:The use of biomaterials has been demonstrated as a viable strategy to promote cell survival and cardiac repair. However, limitations on combinational cell-biomaterial therapies exist, as cellular behavior is influenced by the microenvironment and physical characteristics of the material. Among the different scaffolds ...

journal_title：Cell transplantation

authors： Gaetani R,Yin C,Srikumar N,Braden R,Doevendans PA,Sluijter JP,Christman KL

更新日期：2016-01-01 00:00:00

abstract：:Digital ulcers (DUs) are a rather frequent and invalidating complication in systemic sclerosis (SSc), often showing a very slow or null tendency to heal, in spite of the commonly used systemic and local therapeutic procedures. Recently, stem cell therapy has emerged as a new approach to accelerate wound healing. In th...

journal_title：Cell transplantation

authors： Del Papa N,Di Luca G,Sambataro D,Zaccara E,Maglione W,Gabrielli A,Fraticelli P,Moroncini G,Beretta L,Santaniello A,Sambataro G,Ferraresi R,Vitali C

更新日期：2015-01-01 00:00:00

abstract：:Experiments on spinal cord injury (SCI) have largely focused on the transplantation of stem cells into injured spinal cords for motor recovery while neglecting to investigate bladder dysfunction. The present study was performed to investigate the effect of B10 human mesenchymal stem cells (hMSCs) directly transplanted...

journal_title：Cell transplantation

authors： Lee HJ,An J,Doo SW,Kim JH,Choi SS,Lee SR,Park SW,Song YS,Kim SU

更新日期：2015-01-01 00:00:00

abstract：:Mononuclear stem cells have been studied for their potential in myocardial ischemia. In our previous published article, ReACT(®) phase I/II clinical trial, our results suggest that a certain cell population, promonocytes, directly correlated with the perceived angiogenesis in refractory angina patients. This study is ...

journal_title：Cell transplantation

authors： Hossne NA,Cruz E,Buffolo E,Coimbra AC,Machado J,Goldenberg RC,Regazzi G,Azevedo S,Invitti AL,Rodrigues Branco JN,Rodrigues de Oliveira JS,Stolf NA,Miller LW,Sanberg PR

更新日期：2015-01-01 00:00:00

abstract：:Magnetic targeting has the potential to enhance the therapeutic effects of stem cells through increasing retention of transplanted cells. To investigate the effects of magnetic targeting intensities on cell transplantation, we performed different magnetic intensities for mesenchymal stem cell (MSC)-targeting therapy i...

journal_title：Cell transplantation

authors： Shen Y,Liu X,Huang Z,Pei N,Xu J,Li Z,Wang Y,Qian J,Ge J

更新日期：2015-01-01 00:00:00

abstract：:Efficient maintenance of the undifferentiated status of embryonic stem cells (ESCs) may be important for preparation of high-quality cell sources that can be successfully used for stem cell research and therapy. Here we tried to identify a compound that can enhance the quality of pluripotent stem cells. Treatment of E...

journal_title：Cell transplantation

authors： Han D,Kim HJ,Choi HY,Kim B,Yang G,Han J,Dayem AA,Lee HR,Kim JH,Lee KM,Jeong KS,Do SH,Cho SG

更新日期：2015-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of t...

journal_title：Cell transplantation

authors： Kološa K,Motaln H,Herold-Mende C,Koršič M,Lah TT

更新日期：2015-01-01 00:00:00

abstract：:Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In the present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro and metastasis in vivo. To explore the mechanisms, the character...

journal_title：Cell transplantation

authors： Ma F,Chen D,Chen F,Chi Y,Han Z,Feng X,Li X,Han Z

更新日期：2015-01-01 00:00:00

abstract：:We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers (Fr25lin(-)) have the capacity to differentiate and contribute to regeneration of injured islets. In this study, we assess some of the characteristics of these cells compa...

journal_title：Cell transplantation

authors： Iskovich S,Goldenberg-Cohen N,Sadikov T,Yaniv I,Stein J,Askenasy N

更新日期：2015-01-01 00:00:00

abstract：:We previously demonstrated that mesenchymal cells from human amniotic membrane (hAMTCs) inhibit the generation and maturation of monocyte-derived dendritic cells (DCs) in vitro. Considering the crucial role of DCs in the immune response and that epithelial cells of the human amniotic membrane (hAECs) share some of the...

journal_title：Cell transplantation

authors： Magatti M,Caruso M,De Munari S,Vertua E,De D,Manuelpillai U,Parolini O

更新日期：2015-01-01 00:00:00

abstract：:Cell-based therapy for the bladder has its beginnings in the 1990s with the successful isolation and culture of bladder smooth muscle cells. Since then, several attempts have been made to artificially implant native cell types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or ...

journal_title：Cell transplantation

authors： Gopinath C,Ponsaerts P,Wyndaele JJ

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular diseases are related to many risk factors, such as diabetes, high blood pressure, smoking, and obesity. Myocardial infarction (MI), a cardiovascular disease, is the most common cause of cardiomyocyte death. In MI, hypoxia induces cardiomyocyte apoptosis; in particular, diabetes combined with MI has a sy...

journal_title：Cell transplantation

authors： Huang CY,Chen SY,Fu RH,Huang YC,Chen SY,Shyu WC,Lin SZ,Liu SP

更新日期：2015-01-01 00:00:00

abstract：:Nowadays, cardiac regenerative medicine is facing many limitations because of the complexity to find the most suitable stem cell source and to understand the regenerative mechanisms involved. Mesenchymal stem cells (MSCs) have shown great regenerative potential due to their intrinsic properties and ability to restore ...

journal_title：Cell transplantation

authors： Siciliano C,Chimenti I,Ibrahim M,Napoletano C,Mangino G,Scafetta G,Zoccai GB,Rendina EA,Calogero A,Frati G,De Falco E

更新日期：2015-01-01 00:00:00

abstract：:Traumatic brain injury (TBI), a major contributor to deaths and permanent disability worldwide, has been recently described as a progressive cell death process rather than an acute event. TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ...

journal_title：Cell transplantation

authors： De La Peña I,Sanberg PR,Acosta S,Lin SZ,Borlongan CV

更新日期：2015-01-01 00:00:00

abstract：:This study aimed to identify the beneficial effects of adipose tissue-derived mesenchymal stem cells (ASCs) and ASCs that overexpress the CTLA4Ig gene (CTLA4Ig-ASCs) on established autoimmune thyroiditis and to examine changes in clinical chemistry parameters and the presence of humoral responses upon repeated long-te...

journal_title：Cell transplantation

authors： Choi EW,Lee JM,Lee HW,Yang J,Youn HY

更新日期：2015-01-01 00:00:00

abstract：:In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells (BMMSCs) transfected with connective ti...

journal_title：Cell transplantation

authors： Zhu S,Zhang B,Man C,Ma Y,Liu X,Hu J

更新日期：2014-04-01 00:00:00

abstract：:Isolation of islets from market-sized pigs is costly, with considerable islet losses from fragmentation occurring during isolation and tissue culture. Fetal and neonatal pigs yield insulin unresponsive islet-like cell clusters that become glucose-responsive after extended periods of time. Both issues impact clinical a...

journal_title：Cell transplantation

authors： Lamb M,Laugenour K,Liang O,Alexander M,Foster CE,Lakey JR

更新日期：2014-03-01 00:00:00

abstract：:Early graft loss in islet transplantation means that a large amount of donor islets is required. Endothelial cells and endothelial colony-forming cells (ECFCs) have been reported to improve instant blood-mediated inflammatory reaction (IBMIR) in vitro. In this study, we examined if ECFC-coated porcine islets would pre...

journal_title：Cell transplantation

authors： Jung HS,Kim MJ,Hong SH,Lee YJ,Kang S,Lee H,Chung SS,Park JS,Park KS

更新日期：2014-03-01 00:00:00

abstract：:Recently, animal studies have demonstrated the efficacy of endothelial progenitor cell (EPC) therapy for diabetic wound healing. Based on these preclinical studies, we performed a prospective clinical trial phase I/IIa study of autologous G-CSF-mobilized peripheral blood (PB) CD34(+) cell transplantation for nonhealin...

journal_title：Cell transplantation

authors： Tanaka R,Masuda H,Kato S,Imagawa K,Kanabuchi K,Nakashioya C,Yoshiba F,Fukui T,Ito R,Kobori M,Wada M,Asahara T,Miyasaka M

更新日期：2014-02-01 00:00:00

abstract：:Tissue damage by ischemia/reperfusion (I/R) results from a temporary cessation of blood flow followed by the restoration of circulation. The injury depresses mitochondrial respiration, increases the production of reactive oxygen species (ROS), decreases the mitochondrial transmembrane potential, and stimulates invasio...

journal_title：Cell transplantation

authors： Beiral HJ,Rodrigues-Ferreira C,Fernandes AM,Gonsalez SR,Mortari NC,Takiya CM,Sorenson MM,Figueiredo-Freitas C,Galina A,Vieyra A

更新日期：2014-02-01 00:00:00

abstract：:A human embryonic stem cell (HESC) line, H1, was studied after differentiation to a dopaminergic phenotype in vitro in order to carry out in vivo studies in Parkinsonian monkeys. To identify morphological characteristics of transplanted donor cells, HESCs were transfected with a GFP lentiviral vector. Gene expression ...

journal_title：Cell transplantation

authors： Wakeman DR,Weiss S,Sladek JR,Elsworth JD,Bauereis B,Leranth C,Hurley PJ,Roth RH,Redmond DE

更新日期：2014-01-01 00:00:00

abstract：:Cells derived from the placenta have become the focus of extensive research concerning their ability to be used for regenerative medicine or cellular therapies. In a previous study, we characterized amnion-derived multipotent progenitor cells, or AMP cells, by in vitro methods and showed they were able to inhibit anti...

journal_title：Cell transplantation

authors： Banas R,Miller C,Guzik L,Zeevi A

更新日期：2014-01-01 00:00:00

abstract：:In human neonates, immature GABAergic interneurons are markedly affected by an excitotoxic insult. While in adults the interest of cell transplantation has been demonstrated in several neurological disorders, few data are available regarding the immature brain. The low survival rate constitutes a strong limitation in ...

journal_title：Cell transplantation

authors： Roux C,Lesueur C,Aligny C,Brasse-Lagnel C,Genty D,Marret S,Laquerrière A,Bekri S,Gonzalez BJ

更新日期：2014-01-01 00:00:00

abstract：:Radiotherapy is an effective treatment for brain tumors but often results in cognitive deficits in survivors. Transplantation of embryonic or brain-derived neural stem/progenitor cells (BNSPCs) ameliorated cognitive impairment after irradiation (IR) in animal models. However, such an approach in patients requires a cl...

journal_title：Cell transplantation

authors： Osman AM,Zhou K,Zhu C,Blomgren K

更新日期：2014-01-01 00:00:00

abstract：:Hepatocyte transplantation is an alternative therapy to orthotopic liver transplantation for the treatment of liver diseases. However, the supply of hepatocytes is limited given the shortage of organs available to isolate good-functioning quality cells. Neonatal livers may be a potential source alternative to adult li...

journal_title：Cell transplantation

authors： Tolosa L,Pareja-Ibars E,Donato MT,Cortés M,López S,Jiménez N,Mir J,Castell JV,Gómez-Lechón MJ

更新日期：2014-01-01 00:00:00

abstract：:Autism spectrum disorders (ASDs) are heterogeneous complex neurodevelopmental pathologies defined by behavioral symptoms, but which have well-characterized genetic, immunological, and physiological comorbidities. Despite extensive research efforts, there are presently no agreed upon therapeutic approaches for either t...

journal_title：Cell transplantation

authors： Bradstreet JJ,Sych N,Antonucci N,Klunnik M,Ivankova O,Matyashchuk I,Demchuk M,Siniscalco D

更新日期：2014-01-01 00:00:00

abstract：:The main challenge of cell transplantation as a treatment of myopathies is the large amount of tissue to treat. Intravascular delivery of cells may be an ideal route if proven to be effective and safe. Given the importance of nonhuman primates for preclinical research in transplantation, we tested the intra-arterial i...

journal_title：Cell transplantation

authors： Skuk D,Tremblay JP

更新日期：2014-01-01 00:00:00

abstract：:Insufficient oxygenation can limit the long-term survival of encapsulated islets in subcutaneous tissue. Transplantation of coencapsulated pig islets with adipose or bone marrow mesenchymal stem cells (AMSCs or BM-MSCs, respectively) was investigated with regard to implant vascularization, oxygenation, and diabetes co...

journal_title：Cell transplantation

authors： Vériter S,Gianello P,Igarashi Y,Beaurin G,Ghyselinck A,Aouassar N,Jordan B,Gallez B,Dufrane D

更新日期：2014-01-01 00:00:00

abstract：:Recently, FDA approved the clinical use of autologous fibroblasts (LAVIV™) for the improvement of nasolabial fold wrinkles in adults. The use of autologous fibroblasts for the augmentation of dermal and subcutaneous defects represents a potentially exciting natural alternative to the use of other filler materials for ...

journal_title：Cell transplantation

authors： Zeng W,Zhang S,Liu D,Chai M,Wang J,Zhao Y

更新日期：2014-01-01 00:00:00

abstract：:In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs) improved functional outcome in rats with chronic cerebral infarction. Based on this finding, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n = 15) and control group (n = 15)] with middle cer...

journal_title：Cell transplantation

authors： Chen DC,Lin SZ,Fan JR,Lin CH,Lee W,Lin CC,Liu YJ,Tsai CH,Chen JC,Cho DY,Lee CC,Shyu WC

更新日期：2014-01-01 00:00:00

abstract：:Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases. However, these diseases all have the common characteristic that they are due to degenerative irreversibility, and thus no efficien...

journal_title：Cell transplantation

authors： Chan TM,Chen JY,Ho LI,Lin HP,Hsueh KW,Liu DD,Chen YH,Hsieh AC,Tsai NM,Hueng DY,Tsai ST,Chou PW,Lin SZ,Harn HJ

更新日期：2014-01-01 00:00:00

abstract：:The transplantation of porcine islets of Langerhans to treat type 1 diabetes may provide a solution to the demand for insulin-producing cells. Porcine islets encapsulated in agarose-agarose macrobeads have been shown to function in nonimmunosuppressed xenogeneic models of both streptozotocin-induced and autoimmune typ...

journal_title：Cell transplantation

authors： Holdcraft RW,Gazda LS,Circle L,Adkins H,Harbeck SG,Meyer ED,Bautista MA,Martis PC,Laramore MA,Vinerean HV,Hall RD,Smith BH

更新日期：2014-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) migrate to injury sites and aid in tissue repair. However, clinical success is poor and is partially due to limited HSC recruitment. We hypothesized that HSC pretreatment with H2O2 would enhance their recruitment to injured gut. As HSCs are rare cells, the number of primary cells obtain...

journal_title：Cell transplantation

authors： Kavanagh DP,Yemm AI,Alexander JS,Frampton J,Kalia N

更新日期：2013-01-01 00:00:00

abstract：:New treatment paradigms that slow or reverse progression of chronic kidney disease (CKD) are needed to relieve significant patient and healthcare burdens. We have shown that a population of selected renal cells (SRCs) stabilized disease progression in a mass reduction model of CKD. Here, we further define the cellular...

journal_title：Cell transplantation

authors： Kelley R,Bruce A,Spencer T,Werdin E,Ilagan R,Choudhury S,Rivera E,Wallace S,Guthrie K,Jayo M,Xu F,Rao AN,Humphreys BD,Presnell S,Bertram T

更新日期：2013-01-01 00:00:00